What is a lyophilized peptide?
Definition
A lyophilized peptide is one that has been freeze-dried: frozen and then dried under vacuum so the ice sublimates, leaving a dry powder or cake.
Why peptides are lyophilized
Many peptide degradation reactions, including hydrolysis and deamidation, need water or run much faster in solution. Removing water makes the peptide considerably more stable during storage and shipping.
Handling a lyophilized peptide
- Lyophilized powders are hygroscopic: they absorb moisture from the air. Keep vials sealed until needed.
- Let a cold vial reach room temperature before opening it, so moisture does not condense on the powder.
- Store at the temperature on the label, dry and protected from light.
MOTS-c
MOTS-c is supplied as a white lyophilized powder, recorded as its appearance on every certificate.